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Genetic Basis Of Congenital Heart Disease: A Review

DR. SYED SADIQALI A.DR. SYED SHAHNAZ S.DR. PATIL DEEPAK A.

Abstract: Congenital heart disease (CHD) has multifactorial etiology. The complex morphologic events and tissue remodeling take place during heart formation and is accompanied by equally complex mode of gene expression. Recent findings of genes responsible for Congenital heart disease have provided new insights into the genetic basis of heart malformation. Several cardiac Transcription Factors (TFs) involved in heart formation have been identified; but the molecular mechanisms underlying spatiotemporal regulation of transcription within the heart remain unclear. In this review an effort is made to collect data of all Transcription Factors involved in formation of various parts of heart also the association of Congenital heart disease with various chromosomal anomalies is presented. This review helps to provides information about genetic basis of cardiac defects. Many types of genetic testing are currently available; other testing is still in the research phase. Awareness of this rapidly advancing field is important which will help the clinicians to understand, identify, prevent and treat individuals who might be at risk of cardiac pathology at an early stage.

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