Genetic Basis Of Congenital Heart Disease: A Review
DR. SYED SADIQALI A.DR. SYED SHAHNAZ S.DR. PATIL DEEPAK A.
Congenital heart disease (CHD) has multifactorial etiology. The complex
morphologic events and tissue remodeling take place during heart
formation and is accompanied by equally complex mode of gene
expression. Recent findings of genes responsible for Congenital heart
disease have provided new insights into the genetic basis of heart
malformation. Several cardiac Transcription Factors (TFs) involved in
heart formation have been identified; but the molecular mechanisms
underlying spatiotemporal regulation of transcription within the heart
remain unclear. In this review an effort is made to collect data of all
Transcription Factors involved in formation of various parts of heart
also the association of Congenital heart disease with various
chromosomal anomalies is presented. This review helps to provides
information about genetic basis of cardiac defects. Many types of genetic
testing are currently available; other testing is still in the research phase.
Awareness of this rapidly advancing field is important which will help
the clinicians to understand, identify, prevent and treat individuals who
might be at risk of cardiac pathology at an early stage.