Lipid Profile parameters assessment in Type 2 diabetics having normo and microalbuminuria

Jankar JS, Harley K, Mohod K.

Background: Diabetes is a metabolic disorder characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Aim: To study relation between serum lipid profile and blood glucose, assuming that early finding and treating lipid abnormalities can reduce the impending risk for vascular accident in patients with Type 2 diabetes mellitus. Material and methods: 24 hr urine sample was collected and processed for presence of microalbuminuria. Based on the concentration of albumin in urine, patients were categorised in two groups, group 1 had normoalbuminuria (i.e. Urine Albumin <20 mg/ 24 hr) and group 2 had microalbuminuria (i.e. Urine Albumin 20-300 mg/24 hr). Then, lipid profile parameters were assessed and compared in these groups. Results: The lipid profile parameters Total Cholesterol (TC), Triglycerides (TG), Very Low Density Lipoprotein (VLDL) were found to significantly raised in Group 2 subjects as compared to Group l subjects with p-value < 0.001, whereas High Density Lipoprotein (HDL) was significantly decreased in Group 2 as compared to Group l with p value < 0.001. Conclusion: Dyslipidemia is one of the causative agents for atherosclerosis. Lipid profile parameters along with microalbuminuria should be done in diabetics to decrease cardiovascular mortality and morbidity.

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