Screening of Newborns for Sickle Cell Disease by Automated High Performance
Sonone KK, Abhichandani LG, Sawale VM.
Sickle cell disease is a congenital genetic disorder with significant global
public health issue with numerous Complications. Newborn screening
helps to diagnose the disease even before the development of sign and
symptoms which usually does not occur before 4 months of age. This would
enable early detection and therefore early management that can improve
both morbidity and mortality.
1. To screen for sickle cell disease and sickle cell trait in full term
newborns delivered in J.J Hospital over a period of two months.
2. To find the birth prevalence of sickle cell disease and sickle cell
trait among those full term newborns screened.
Settings and Design: This is a prospective, randomised, single centric,
non-interventional, open labelled study.
Methods and Material: Umbilical cord blood (100 samples) of the
newborn was taken. Automated HPLC (high performance liquid
chromatography - BIORAD VARIANTTM) was performed.
Results: We found that, birth prevalence of sickle cell trait was two out of
hundred births i.e. 2 percent among the total population and 8% among
backward and tribal communities of our society.
Conclusions: 8 percent( present study)sickle cell trait prevalence among
backward and tribal communities should be taken into consideration for
recommending a universal neonatal screening program in highly
prevalent areas of India to identify babies with sickle cell disease and
commence comprehensive care.