Study of Serum Homocysteine Status in Patients with Acute Pancreatitis in a Medical College & Hospital of Odisha

KHAN ANAGHA JYOTI, CHAKRABORTY SOURAV, MODAK SUDIPTA, MAHAPATRA TK, MAHAPATRA RK, DAS KL

Homocysteine plays a established role in coronary artery disease. It also plays a siginificant role in inflammation and malignancy as studied experimentally. Few have suggested that a relationship might exist between pancreatitis and homocystinuria, possibly due to occlusive vascular disease of the pancreas. As of now, serum homocysteine levels in pancreatic disease have not been studied effectively. We aimed to analyze the homocysteine status in patients with acute pancreatitis, and the changes of the serum homocysteine level at the acute onset of the disease. 25 acute pancreatitis patients and 25 healthy subjects were studied. Serum homocysteine, vitamin B12, folate, amylase, lipase, C-reactive protein, total cholesterol, HDL and LDL cholesterol, triglycerides, blood urea nitrogen, white blood cells and creatinine were measured in the two groups of subjects. Levels of homocysteine were significantly increased in patients with acute pancreatitis along with increase in levels of serum creatinine, blood urea nitrogen, WBC counts, amylase, lipase, and C-reactive protein. Also reduced creatinine clearance was also noted in these patients, however was not statistically significant. Serum total cholesterol, HDL and LDL cholesterol concentrations were apparently similar between the two groups of subjects. Hence our study suggests that homocysteine has a role in acute pancreatitis. Increased serum homocysteine levels in acute pancreatitis could be used a marker, as one of the diagnostic criteria for acute pancreatitis. In conclusion, this particular study is showing that patients with acute pancreatitis have higher serum homocysteine levels than healthy subjects.

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