Study of Serum Uric Acid level in Type 2 DM and its association with Metabolic Syndrome
Shaikh NB, Gadhiya BM, Shendye RJ
Introduction: Endothelial dysfunction by uric acid leads to pathogenesis of hypertension and weight gain. So there is a direct linear relationship between serum uric acid level and number of metabolic syndrome components. Our study aims to relate components of metabolic syndrome with uric acid that could be done routinely as marker of metabolic syndrome. Present study is to estimate level of serum uric acid in patients of type 2 DM having metabolic syndrome and its association with various components of metabolic syndrome.
Materials and methods: Serum uric acid, fasting blood sugar, triglycerides and HDL were measured in 40 type 2 DM patients with metabolic syndrome and 40 healthy controls. BP and anthropometric measurements of all cases and controls were also measured.
Result: Mean of uric acid in cases were significantly higher than controls (7.49+1.14mg/dl vs. 5.25+1.02mg/dl, P<0.001). In our study, uric acid has statistically significant positive correlation with BP, triglyceride, fasting blood sugar and abdominal obesity and negative correlation seen with HDL cholesterol.
Conclusion: Uric acid which can be easily performed at low cost should be considered important factor for risk assessment of CVD and metabolic syndrome.