Tenny Parker change A reflection of placental pathology
DR WARE SANDHYA S, DR NAGARGOJE PRAVIN P, DR PHAD VAIBHAV V, DR SAWAITULDR VINOD K
Pre-eclampsia is a disorder of pregnancy characterized by
hypertension and proteinuria. It is now thought that abnormal
placentation and placenta function is a strong predisposing factor for
pre-eclampsia. Syncytial knots are aggregates of nuclei at the surface
of terminal villi and their number increase with increasing gestational
age. Increased syncytial knots (Tenny parker change) are associated
with conditions of utero-placental malperfusion and are important in
placental examination. Vasculo-syncytial membrane (VSM) is the
primary site of feto-maternal exchange in placenta. In pre-eclampsia,
VSM thickness is increased causing fetal hypoxia.
We here report a case of an autopsy finding in a pre-eclamptic female.
On histopathological examination, we found terminal chorionic villi
with excessive syncytial knots (Tenny Parker change). Syncytial knots
were seen in more than 40% of chorionic villi. Vasculo-syncytial
membrane (VSM) thickness was also increased. Thus,
histopathological findings of Tenny Parker change and increased
vasculo-syncytial membrane (VSM) thickness are the clues for
placental pathology in pre-eclampsia.